This reference discusses advances in the design, optimization, and adaption of gene delivery systems for treatment of cancerous, cardiovascular, pulmonary, genetic, and infectious diseases. Pharmaceutical Gene Delivery Systems also contains assessment and reviews on procedures involved in the development of gene-based pharmaceuticals. It examines the advantages and limitations of the major gene delivery systems, as well as offers guidelines to select the most appropriate viral or synthetic delivery system for specific theraputic applications. Pharmaceutical Gene Delivery: • examines recent breakthroughs in gene therapy • details new technologies such as artificial chromosome delivery • covers the preclinical data required for investigational new drug applicationfiling • exemplifies several therapeutic applications of gene therapy products Contents 1. Introduction to Gene Therapy and Guidelines to Pharmaceutical Development 2. Sustaining Transgene _Expression in Vivo 3. _Expression Systems: Regulated Gene _Expression 4. Mechanisms for Cationic Lipids in Gene Transfer 5. Polymer-Based Gene Delivery Systems 6. Adenoviral Vectors for Gene Delivery 7. Gene Delivery Technology: Adeno-Associated Virus 8. Retrovectors Go Forward 9. Device-Mediated Gene Delivery: A Review 10. Nonviral Approaches for Cancer Gene Therapy 11. Replicating Adenoviral Vectors for Cancer Therapy 12. Cardiovascular Gene Therapy 13. Pulmonary Gene Therapy
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